Overview:
Generalized myasthenia gravis (gMG) is a neuromuscular disease characterized by muscle weakness and fatigue and is considered one of the archetypes for B cell-mediated autoimmune disorders in which regulation of B cell differentiation and activation is disturbed. Thus, one of the approaches being used to treat gMG is to target B cells directly, either by depleting or inhibiting these cell lines or, more indirectly, by targeting their facilitators (eg, cytokines and other immune cells). This continuing education activity will feature expert clinician-researchers discussing the role of B cell pathways in the pathophysiology of gMG and how this provides therapeutic targets and will potentially expand the array of novel therapies available for patients with this condition. The activity is presented in PER’s Expert Illustrations and CommentariesTM
format in which faculty discussions are enriched with the use of video animations to illustrate key points regarding disease pathophysiology and drug mechanism of action. This unique format is designed to help clinicians identify best practices in the management of gMG and to improve outcomes for their patients with the disease.
Learning Objectives:
Upon completion of this activity, participants will be able to:
- Identify the role of B cells in the pathophysiology of gMG
- Evaluate emerging data on targeted therapies for gMG
James F. Howard Jr, MD, FAAN
Professor of Neurology, Medicine, and Allied Health
UNC School of Medicine
The University of North Carolina at Chapel Hill
Chapel Hill, NC
Katherine Ruzhansky, MD, MS
Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physicians’ Education Resource®, LLC, designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians’ Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669, for 1.0 Contact Hours.
