Release Date: November 27, 2024
Expiration Date: November 27, 2025
Activity Overview
This educational initiative, Cases and Conversations: Integrating Novel Approaches to Treatment in First-Line ALK+ mNSCLC—Enhancing Patient Outcomes With Real-World Multidisciplinary Strategies, is designed to equip medical oncologists, thoracic surgeons, pathologists, nurses, nurse practitioners, physician assistants, pharmacists, and other health care professionals with the knowledge and skills needed to optimize patient outcomes. The program will focus on the importance of molecular testing in guiding treatment decisions, the integration of multidisciplinary care approaches, and the application of novel first-line therapies including local consolidative therapy (LCT) with systemic treatments.
Through case-based discussions and real-world scenarios, learners can explore best practices for identifying patient characteristics that influence treatment selection, managing treatment-related adverse events (TRAEs), and implementing evidence-based treatment sequencing strategies for patients with tyrosine kinase inhibitor (TKI)–naive anaplastic lymphoma kinase–positive (ALK+) metastatic non–small cell lung cancer (mNSCLC). This activity is designed to empower health care professionals to apply emerging clinical evidence in their practice, thereby enhancing the quality of care for patients with ALK+ mNSCLC.
This educational activity is an archive of the live symposium held on November 16, 2024.
Target Audience
This educational activity is directed toward physicians, pathologists, advanced practice professionals, nurses, pharmacists, and other health care practitioners interested in NSCLC.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Interpret molecular testing results accurately to guide the selection of targeted therapies in the first-line setting.
- Identify key patient characteristics, including comorbidities, disease stage, and molecular profiles, that influence treatment decisions in ALK+ mNSCLC.
- Apply evidence-based guidelines to select appropriate first-line therapies based on individual patient characteristics.
- Evaluate clinical evidence supporting the use of LCT in combination with chemotherapy for ALK+ mNSCLC.

Mark G. Kris, MD
William and Joy Ruane Chair in Thoracic Oncology
Memorial Sloan Kettering Cancer Center
New York, NY
Disclosures: Consultant: AstraZeneca; Bristol Myers Squibb; Daiichi Sankyo; Merck.

Justin Gainor, MD
Associate Professor of Medicine
Harvard Medical School
Program Director, Center for Thoracic Cancers
Director, Targeted Immunotherapy
Massachusetts General Hospital
Boston, MA
Disclosures: Grant/Research Support Paid to Institution: Adaptimmune, Alexo, Array BioPharma, AstraZeneca, Blueprint Medicines, Bristol Myers Squibb, Jounce Therapeutics, Merck, Moderna, Novartis, Palleon Pharmaceuticals, Tesaro; Consultant: Bristol Myers Squibb, Genentech/Roche Group, Gilead Sciences, iTeos Therapeutics, Jounce Therapeutics, Karyopharm Therapeutics, Loxo Oncology/Lilly, Mariana Oncology, Merck, Merus, Mirati Therapeutics, Moderna, Novartis, Novocure, Nuvalent, Pfizer, Silverback Therapeutics, Takeda.

Isabel Preeshagul, DO, MBS
Thoracic Medical Oncologist
Assistant Attending Physician
Memorial Sloan Kettering Cancer Center
Montvale, NJ
Disclosures: Other: Scientific Advisory: AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Genentech, GI Therapeutics, Pfizer, Regeneron, Takeda.

Helena A. Yu, MD
Thoracic Medical Oncologist and Early Drug Development Specialist
Associate Attending Physician
Memorial Sloan Kettering Cancer Center
New York, NY
Disclosures: Consultant: AbbVie, Amgen, AstraZeneca, Bristol Myers Squibb, Cullinan, Daiichi Sankyo, Ipsen, Janssen, Takeda; Other: Data and Safety Monitoring Board: Janssen, Mythic Therapeutics.
Faculty, Staff, and Planners’ Disclosures
The staff of Physicians’ Education Resource®, LLC, have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER or any company that provided commercial support for this activity.

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