Release Date: December 21, 2022
Expiration Date: December 21, 2023
Activity Overview
HER2 is an important emerging target of interest in gastrointestinal (GI) malignancies, most notably in the context of esophagogastric cancer, where multiple anti-HER2–based treatment approaches are now available. This online, on-demand educational activity brings together leading clinician-researchers to provide insight on the current state of the art with respect to anti-HER2 therapy in GI oncology. By coupling expert faculty commentary with case discussions, this tumor board highlights current best practices and areas in which potential future treatment options may fit into the standard of care for HER2-positive GI tumors.
Target Audience
This educational activity is directed toward pathologists, oncologists, nurses, and other healthcare professionals involved in the treatment of GI malignancies.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
• Discuss the rationale underlying the application of HER2-trageted therapies in GI malignancies and testing strategies to identify appropriate patients who would benefit from HER2-targeted therapy
• Explain recent data from clinical trials evaluating current and emerging HER2-targeted therapies for the treatment of GI malignancies
• Determine approaches to personalize care for patients with HER2-positive GI cancers by integrating guideline-based recommendations in parallel with emerging evidence
• Apply best practices for proactively monitoring for and mitigating adverse events related to HER2-targeted therapies for GI cancers

David H. Ilson, MD, PhD
Professor of Medicine
Weill Cornell Medical College
Attending Physician and Member
Department of Medicine/Solid Tumor Service
Memorial Sloan Kettering Cancer Center
New York, NY
Disclosures: Consultant: Amgen, Astellas, Astra Zeneca, Bayer, Bristol Myers Squibb, Merck, Daiichi Sankyo, Lilly, Taiho, Roche.

Ryan B. Corcoran, MD, PhD
Director, GI Cancer Center Program
Massachusetts General Hospital Cancer Center
Boston, MA
Disclosures: Grant/Research Support: Lilly, Novartis, Pfizer; Consultant: Alterome Therapeutics, C4 Therapeutics, Cogent Biosciences, Erasca, Interline Therapeutics, Kinnate Biopharma, Nested Therapeutics, nRichDX, Qiagen, Remix Therapeutics, Revolution Medicines, Taiho, Theonys; Stock/Shareholder: Alterome Therapeutics, Avidity Biosciences, C4 Therapeutics, Cogent Biosciences, Erasca, Interline Therapeutics, Kinnate Biopharma, Nested Therapeutics, nRichDX, Remix Therapeutics, Revolution Medicines, Theonys.

Geoffrey Ku, MD
Assistant Attending Physician
Head, Esophagogastric Section, Gastrointestinal Oncology Service
Member, Cellular Therapy Service
Department of Medicine
Memorial Sloan Kettering Cancer Center
New York, NY
Disclosures: Grant/Research Support: Adaptimmune, AstraZeneca, BMS, CARsgen, Daiichi Sankyo, Merck, Oncolys, Pieris, Zymeworks; Consultant: AstraZeneca, BMS, Daiichi Sankyo, Merck, Pieris, Zymeworks.
Faculty, Staff, and Planners’ Disclosures
The staff of Physicians’ Education Resource®, LLC, have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.

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