Activity Overview
Lambert-Eaton myasthenic syndrome (LEMS) is a rare, frequently under-recognized paraneoplastic neurologic disorder that may occur in patients with small cell lung cancer (SCLC). Overlapping features with myasthenia gravis, chemotherapy-induced neuropathy, or deconditioning often delay diagnosis, leading to significant morbidity, functional decline, and missed opportunities to identify SCLC earlier.
This satellite symposium was presented in conjunction with the 2026 International Association for the Study of Lung Cancer Winter Lung Cancer Conference. Using a case-based format, our expert faculty highlight hallmark clinical clues, outline evidence-based diagnostic pathways, and provide strategies for optimizing care with available therapies and multidisciplinary coordination. By addressing real-world challenges in recognition and management, the session aims to equip clinicians with actionable tools to improve patient outcomes for SCLC and LEMS.
This educational activity is an archive of the live presentation held on Friday, January 23, 2026.
For more information about this educational activity, the faculty, and disclosures, please click here.
Target Audience
This educational activity is directed toward oncologists involved in treating patients with lung cancers. Neurologists, nurse practitioners, nurses, physician assistants, pharmacists, researchers, fellows, and other health care professionals interested in the treatment of lung cancers may also participate.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Recognize key clinical features and red flags of paraneoplastic LEMS
- Integrate guideline-recommended processes for diagnosing LEMS and evaluating patients for underlying malignancy
- Implement evidence-based treatment for LEMS and alignment with SCLC therapy
- Evaluate treatment-related toxicities associated with LEMS and SCLC therapies
Charles Rudin, MD, PhD
Thoracic Medical Oncologist
Cancer Center Deputy Director
Co-Director, Druckenmiller Center for Lung Cancer Research
Sylvia Hassenfeld Chair in Lung Cancer Research
Memorial Sloan Kettering Cancer Center
New York, NY
Ruham Nasany, MD
Assistant Professor, Department of Neurology
Director, In-patient Neuro Oncology Service
Co-Leader, Neuro Oncology Site Disease Group
Sylvester Comprehensive Cancer Center
University of Miami, Miller School of Medicine
Miami, FL
Zofia Piotrowska, MD, MHS
Associate Professor of Medicine
Harvard Medical School
Clinical Co-Director, MGB Thoracic Medical Oncology Program
Mass General Brigham Cancer Institute
Massachusetts General Hospital
Boston, MA
The staff of Physicians’ Education Resource®, LLC have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.
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