Overview:
Crosstalk between adaptive and CNS-resident innate immune systems has
been identified as an essential component underlying the pathophysiology of multiple
sclerosis (MS). The role of the cluster of differentiation 40 (CD40/CD40 ligand
(CD40L) costimulatory signaling pathway in this process has been elucidated.
CD40 is expressed on B cells, while CD40L is expressed on antigen-activated T
cells. The impact of this pathway on adaptive immune cells includes activation
and proliferation of B cells, antigen presentation and antibody production, as
well as T cell activation, Th cell differentiation, and production of
inflammatory cytokines. On the innate immune system side, it may contribute to
activation of macrophages/microglia and dendritic cells, antigen presentation,
and the production of inflammatory cytokines. This
provides an additional potential therapeutic target for patients with MS.
Learning Objectives:
Upon completion of this activity, learners should be able to:
- Implement approaches to evaluating neuroinflammation in patients with MS
- Identify the unmet needs in the treatment of patients with MS
- Describe the role of the CD40/CD40L pathway in the pathophysiology of MS
Stephen C. Krieger, MD, FAAN
Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physicians’ Education Resource®, LLC designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians’ Education Resource®, LLC is approved by the California Board of Registered Nursing, Provider #16669, for 1.0 Contact Hour.