Activity Overview
Welcome to this OncoByte Adaptive Learning Pathway!
Each OncoByte video features a 5-minute presentation by our expert faculty on a key foundational topic related to the use of TROP2-targeting antibody-drug conjugates (ADCs) in the treatment of non–small cell lung cancer (NSCLC). Prior to watching an OncoByte, you will be asked a question on the topic to assess your baseline knowledge and confidence. If you answer the question correctly and confidently, you will continue to the next topic. If you answer the question incorrectly or without high confidence, you will continue to the OncoByte video.
After proceeding through your customized learning pathway, you will be led to panel discussions. Our expert faculty will help you synthesize the latest information and data on the safety and efficacy of TROP2-targeting ADCs in patients with NSCLC.
Target Audience
This educational activity is directed toward a global audience of oncology clinicians, including medical oncologists, thoracic oncologists, pulmonologists, advanced practice providers, oncology nurses, pharmacists, and other members of the multidisciplinary cancer care team involved in the management of patients with NSCLC.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Assess recent clinical trial and emerging pipeline data for TROP2-targeted ADCs and combination strategies in NSCLC
- Select evidence-informed treatment and sequencing strategies for patients with NSCLC across relevant biomarker subsets
- Evaluate appropriate interpretation of exploratory CNS activity signals for TROP2-targeted ADCs
- Implement multidisciplinary strategies to monitor, mitigate, and manage high-impact toxicities associated with TROP2-targeted ADCs

Solange Peters, MD, PhD
Full Professor
Chair of Medical Oncology and Oncology Program
University Hospital of Lausanne
Lausanne, Switzerland
Disclosures: Consultation/Advisory Role (all fees to institution): AbbVie, Amgen, Arcus, AstraZeneca, Bayer, BeiGene, BerGenBio, Bicycle Therapeutics, Biocartis, BioInvent, BioNTech, Blueprint Medicines, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Debiopharm, Eli Lilly, Foundation Medicine, F-Star, Genmab, Genzyme, Gilead, GSK, HUTCHMED, Illumina, Incyte, Ipsen, iTeos, Janssen, Merck Serono, Merck Sharp & Dohme, Novartis, Novocure, Nuvalent, Nuvation Bio, Nykode Therapeutics, Pfizer, Pharma Mar, Promontory Therapeutics, Qlucore, Regeneron, Roche/Genentech, Sanofi, Takeda, Zymeworks; Speakers Bureau (all fees to institution): AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Foundation Medicine, GSK, Illumina, Ipsen, Merck Sharp & Dohme, Novartis, Pfizer, Roche/Genentech, Sanofi, Takeda; Grant/Research Funding (to institution): Amgen, Arcus, AstraZeneca, BeiGene, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, GSK, iTeos, Merck Sharp & Dohme, Mirati, Pfizer, Pharma Mar, Promontory Therapeutics, Roche/Genentech.

Myung-Ju Ahn, MD, PhD
Professor
Section of Hematology-Oncology
Department of Medicine
Hanyang University Medical Center
Hanyang University College of Medicine
Seoul, Korea
Disclosures: Advisor, Consultant, Fee-for-Service Recipient: Aimed Bio, Amgen, AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Genexine, Merck, MSD, Roche, Takeda, Voronoi

Benjamin P. Levy, MD
Associate Professor of Oncology
Johns Hopkins University School of Medicine
Clinical Director of Medical Oncology
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Sibley Memorial Hospital
Washington, DC
Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: AstraZeneca, DSI, Johnson & Johnson (Janssen), Merck, Pfizer

Stephanie McDonald, FNP-BC, AOCNP
Nurse Practitioner
Department of Thoracic Oncology
Dana-Farber Cancer Institute
Boston, MA
Disclosures: Stephanie McDonald, FNP-BC, AOCNP, has no relevant financial relationships with ineligible companies.

Tony S.K. Mok, MD, BMSc, FRCP(C), FRCP(Edin), FHKCP, FHKAM(Medicine), FASCO
Associate Dean (Translation and Entrepreneurship)
Chairman, Department of Clinical Oncology
Li Shu Fan Professor of Clinical Oncology
Chinese University of Hong Kong
Sha Tin, Hong Kong
Disclosures: Advisor, Consultant, Fee-for-Service Recipient: AbbVie Inc, ACEA Pharma, Alentis Therapeutics AG, Amgen, AstraZeneca, BerGenBio ASA, Berry Oncology, Blueprint Medicines Corporation, Boehringer Ingelheim, Bowtie Life Insurance Co Ltd, Bristol Myers Squibb, C4 Therapeutics Inc, Covidien LP, CStone Pharmaceuticals, Curo Science, D3 Bio Ltd, Daiichi Sankyo Inc, Daiichi Sankyo Company Limited, Eisai, Fishawack Facilitate Ltd, G1 Therapeutics Inc, geneDecode Co Ltd (uncompensated), Gilead Sciences Inc, Gritstone Oncology Inc, Guardant Health, Hengrui Therapeutics Inc, HUTCHMED, Ignyta Inc, Imagene AI LTD, Incyte Corporation, Inivata, IQVIA, Janssen, Lakeshore Biotech, Lilly, Loxo Oncology Inc, Lunit Inc, Merck Serono, Merck Sharp & Dohme, Mirati Therapeutics Inc, Mirxes Group, Novartis, OrigiMed, Ottimo Pharma Limited, Pfizer, Prenetics, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Roche/Genentech, Sanofi-Aventis R&D, SFJ Pharmaceuticals; Speakers Bureau: ACEA Pharma, Alpha Biopharma Co Ltd, Amgen, Amoy Diagnostics Co Ltd, AstraZeneca (before January 1, 2019), BeiGene, Beijing China council for the promotion of chronic diseases prevention and control of traditional Chinese and western medicine, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Daz Group, eDoctor Healthcare Technology, Fishawack Facilitate Ltd, Fundación Canaria del Grupo Gestión De Cáncer De Pulmón, InMed Medical Communication, Janssen Pharmaceutica NV, Jiahui Holdings Co Limited, LiangYiHui Healthcare, Lilly, Lucence Health Inc, MD Health Brazil, Medscape LLC, Merck Pharmaceutical HK Ltd, Merck Sharp & Dohme, Mirxes, Novartis, OrigiMed Co Ltd, P. Permanyer SL, PeerVoice, Pfizer, Pierre Fabre Group, Dermo-Cosmetique Hong-Kong Limited, PRIME Oncology, Research to Practice, Roche Pharmaceuticals/Diagnostics/Found; Grant/Research Funding: AstraZeneca, BMS, G1 Therapeutics, Merck Serono, MSD, Novartis, Pfizer, Roche, SFJ, Takeda, XCovery; Ownership Interests in Privately Held Companies: Alentis Therapeutics AG, AstraZeneca, Aurora Tele-Oncology Ltd, Biolidics Ltd, Bowtie Life Insurance Co. Ltd, D3 Bio, HutchMed, Insighta, Lakeshore Biotech Ltd, Loxo Oncology, Lunit USA Inc, Phanes Therapeutics Inc, Prenetics, Virtus Medical Group

Antonio Passaro, MD, PhD
Medical Director With High Specialization Responsibility
Division of Thoracic Oncology
European Institute of Oncology, IRCCS
Milan, Italy
Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: AbbVie, ArriVent, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Cullinan Oncology, Daiichi Sankyo, Eli Lilly, Gilead, GSK, Janssen, Johnson & Johnson, Merck Sharp and Dohme, Mundipharma, Novartis, Pfizer, Roche/Genentech, Sanofi, Summit Therapeutics; Speakers Bureau: AbbVie, AiCME, AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, ecancer, Eli Lilly, Janssen, Johnson & Johnson, Medscape, Merck Sharp and Dohme, PeerView, PeerVoice, Takeda, touchONCOLOGY; Grant/Research Funding (to institution): ArriVent, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol Myers Squibb, Cullinan Oncology, Daiichi Sankyo, Eli Lilly, Janssen, Johnson & Johnson, Merck Serono, Merck Sharp and Dohme, Mirati, MRC, Pfizer, Roche/Genentech, Summit Therapeutics

Luis Paz-Ares, MD, PhD
Chair, Medical Oncology Department
Hospital Universitario 12 de Octubre
Associate Professor
Universidad Complutense de Madrid
Head, Lung Cancer Unit
National Oncology Research Center
Madrid, Spain
Disclosures: Advisor, Consultant, Fee-for-Service Recipient: Amgen, AstraZeneca, Bayer, BeOne (BeiGene), BioNTech, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Eli Lilly, Genmab, Gilead, GSK, Ipsen, Jazz Pharmaceuticals, Johnson & Johnson, Merck Serono, Merck Sharp & Dohme, Mirati Therapeutics, Novartis, Ottimo Pharma, Pfizer, PharmaMar, Pierre Fabre, Regeneron, Roche/Genentech, Sanofi, Takeda; Speakers Bureau: Bristol Myers Squibb, Eli Lilly, Merck Serono, Merck Sharp & Dohme Oncology, Pfizer, Roche/Genentech; Leadership Role: ALTUM sequencing, Stab Therapeutics

Maurice Pérol, MD
Lead
Thoracic Oncology Program
Medical Oncologist
Léon Bérard Cancer Centre
Lyon, France
Disclosures: Advisor, Consultant, Fee for Service Recipient: AbbVie, Amgen, AstraZeneca, Bristol Myers Squibb, Ipsen, Janssen, Merck Sharp & Dohme, Pfizer, Sanofi, Takeda; Speakers Bureau: AstraZeneca

Jacob Sands, MD
Associate Chief, Lowe Center for Thoracic Oncology
Dana-Farber Cancer Institute
Assistant Professor
Harvard Medical School
Boston, MA
Disclosures: Advisor, Consultant, Speaker, Honoraria Recipient: AbbVie, Amgen, AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Fosun, Genentech, Gilead, Jazz Pharmaceuticals, Medtronic, Merck, Novartis, Pfizer, Sanofi; Grant/Research Funding: Amgen, Harpoon, Novartis
The staff of Physicians’ Education Resource®, LLC have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.






