Release Date: June 30, 2025
Expiration Date: June 30, 2026
Activity Overview
This Expert Illustrations & Commentaries™ is a video-based program in which 2 experts discuss key clinical aspects of paroxysmal nocturnal hemoglobinuria (PNH). In this activity, the faculty focus on pathophysiology and therapeutic strategies for the management of PNH. Their discussion is enriched by using video animation to illustrate the mechanism of disease and mechanism of action of therapies. The use of these animated segments helps make the somewhat complicated subject matter more easily understood. This unique format is designed to help clinicians identify best practices in the diagnosis and management of PNH.
Target Audience
This educational activity is directed toward hematologists, specialty NPs, PAs, RNs, and other healthcare professionals involved in the management of patients with PNH.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Describe pathophysiological processes that provide therapeutic targets in PNH
- Assess clinical trial data for therapies for PNH
- Formulate individualized management plans for patients with PNH using shared decision-making principles

Caroline Piatek, MD
Associate Professor
USC Keck School of Medicine
Disclosures: Consulting: AstraZeneca/Alexion, J&J, Novartis, Omeros, Sanofi; Speaker: Rigel, Sobi

Ilene Weitz, MD
Professor of Clinical Medicine
USC Keck School of Medicine
Disclosures: Speaker/Consultant: Alexion, AstraZeneca; Research Funding: Novartis
Faculty, Staff, and Planners’ Disclosures
The staff of Physicians’ Education Resource®, LLC, have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a healthcare professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.
