Release Date: February 28, 2023
Expiration Date: February 28, 2024
Activity Overview
This Expert Illustrations and CommentariesTM is a video-based program in which 2 experts discuss strategies for the management of cold agglutinin disease (CAD). In this activity, the faculty focus on the role of the complement system in the pathophysiology of cold agglutinin disease and ways that current and emerging therapies target the pathophysiologic processes at play. The faculty discussion is enriched with the use of video animations to illustrate the complement pathway, as well as the mechanism of action of current and emerging complement-directed therapies. The use of animated segments helps make somewhat complicated subject matter more easily understood. This unique format is designed to help clinicians identify best practices in the treatment of patients with CAD.
Target Audience
This educational activity is directed toward hematologists. Nurses, nurse practitioners, physician assistants, and other clinicians involved in the management of patients with cold agglutinin disease are invited to attend.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Outline the role of the complement pathway in the pathogenesis of CAD
- Implement diagnostic algorithms to accurately identify patients with CAD
- Assess clinical trial data for current and emerging agents used to treat patients with CAD

Jeremy Lorber, MD
Assistant Professor
Department of Medicine
Cedars-Sinai
Los Angeles, CA
Disclosures: Speakers’ Bureau: Sanofi.

Ilene Ceil Weitz, MD
Professor of Medicine
Jane Anne Nohl Division of Hematology
Keck School of Medicine - University of Southern California
Los Angeles, CA
Disclosures: Ilene Ceil Weitz, MD has no relevant financial relationships with ineligible companies.
Faculty, Staff, and Planners’ Disclosures
The staff of Physicians’ Education Resource®, LLC, have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.

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