Release Date: October 30, 2025
Expiration Date: October 30, 2026
Activity Overview
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis globally and an important cause of chronic kidney disease and kidney failure in young adults. As understanding of its complex autoimmune and inflammatory mechanisms deepens, new opportunities are emerging to improve patient outcomes through targeted and individualized therapy.
This CME program will provide clinicians with a comprehensive update on current and emerging strategies for evaluating and managing IgAN. Expert faculty will integrate recent advances in disease pathophysiology, risk assessment, and therapeutic development with practical approaches to patient care.
Target Audience
This educational activity is directed toward nephrologists, nephrology nurses, nurse practitioners, physician assistants, registered nurses, and other health care practitioners involved in the care of patients with IgAN.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Describe the underlying pathophysiologic mechanisms contributing to the development and progression of IgAN
- Apply clinical and laboratory findings to distinguish IgAN from other glomerular diseases in diagnostic decision-making
- Evaluate recent clinical trial evidence related to novel and emerging disease-modifying therapies for the treatment of IgAN
- Develop patient-centered strategies for early detection and intervention in IgAN

Gerald Bernard Appel, MD
Professor of Clinical Medicine
Columbia University College of Physicians and Surgeons
Co-Director, Clinical Nephrology Glomerular Kidney Center
NewYork-Presbyterian Medical Center/Columbia University Medical
Center
New York, NY
Disclosures: Consultant: Apellis, Aurinia, Glaxo, Novartis, Travere; Speaker’s Bureau: Aurinia, Calliditas, Glaxo; Grant and Research Support (through Columbia University): Apellis, Calliditas, Novartis; Other: UpToDate Editor and contributor to IgAN section

Ellie Kelepouris, MD, FACP, FAHA
Professor of Clinical Medicine
Vice Chair for Clinical Affairs
Division of Nephrology
University of Pennsylvania
Philadelphia, PA
Disclosures: Consultant: Bayer; Advisory Board: CSL Vifor, Travere, Vera
Faculty, Staff, and Planners’ Disclosures
The staff of Physicians’ Education Resource®, LLC have no relevant financial relationships with ineligible companies.
PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.
Off-Label Disclosure and Disclaimer
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.

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