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Free CE/CMEVideo

Cases and Conversations: Optimizing Oral SERD-Based Therapy After CDK4/6 Inhibition in HR+/HER2– MBC

Release Date

June 5, 2026

Expiration Date

July 1, 2026

Credits

1.5 CME, NCPD

Specialties

Breast Cancer, Medical Oncology+3 more

Activity Overview

This educational activity is an archive of the live presentation held on May 30, 2026.

For more information about this educational activity, the faculty, and disclosures, please click here.

Target Audience

This educational activity is directed toward oncologists, NPs/PAs, nurses, pharmacists, and other HCPs involved in the management of breast cancer.

Learning Objectives

Upon successful completion of this activity, you should be better prepared to:

  • Implement best practices for molecular testing in HR+/HER2-negative metastatic breast cancer, including selection of tissue vs liquid biopsy and indications for repeat testing at progression.
  • Differentiate between available and emerging oral SERDs based on pivotal trial data, real-world evidence, and patient-specific factors to guide treatment selection in ESR1-mutant disease.
  • Evaluate the role of oral SERD monotherapy versus combination regimens in the post-CDK4/6 inhibitor setting, balancing efficacy with tolerability.
  • Develop individualized treatment strategies for patients with co-occurring ESR1 and PIK3CA mutations, integrating evidence for oral SERDs and PI3K/AKT pathway inhibitors.
    Cases and Conversations: Optimizing Oral SERD-Based Therapy After CDK4/6 Inhibition in HR+/HER2– MBC

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    Accreditation/Credit Designation

    Physicians’ Education Resource®, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Physicians’ Education Resource®, LLC designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Physicians’ Education Resource®, LLC is approved by the California Board of Registered Nursing, Provider #16669, for 1.5 Contact Hours.

    Acknowledgment of Commercial Support

    This activity is supported by an educational grant from Stemline Therapeutics, Inc.

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    Course

    Cases and Conversations: Optimizing Oral SERD-Based Therapy After CDK4/6 Inhibition in HR+/HER2– MBC

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