Cases and Conversations™: Next-Generation Pathology Advances and Considerations for Precision Care in Non–Small Cell Lung Cancer

Overview:

Non–small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide, driven by complex biologic heterogeneity and the rapid expansion of actionable genomic alterations. Although comprehensive molecular profiling—particularly next-generation sequencing (NGS)—has transformed the treatment landscape, many clinicians face significant logistical, operational, and financial barriers to implementing timely, guideline-concordant biomarker testing in routine practice. Persistent gaps in interpreting tissue and liquid biopsy results, managing limited tissue, and selecting appropriate testing modalities underscore an urgent need for focused education.

This CME-certified hybrid satellite symposium uses an interactive Cases and Conversations™ format. A panel of expert thoracic pathologists and medical oncologists will engage in concise didactic segments and case-based discussions to guide learners through real-world diagnostic, molecular, and therapeutic dilemmas across the NSCLC continuum. Faculty will review best practices for optimizing tissue, implementing reflex testing, comparing tissue-based and plasma-based (liquid biopsy) workflows, and integrating novel therapeutics for emerging targets.

Learning Objectives:

Upon completion of this activity, learners will be better able to:

• Interpret tissue and liquid biopsy-based molecular testing results to support appropriate treatment selection for actionable mutations
• Evaluate emerging and established clinical trial data on targeted therapies in NSCLC 
• Identify strategies to overcome barriers to biomarker testing and enhance collaboration between pathology and oncology teams for optimal patient care

Target Audience:

This educational activity is directed toward pathologists, as well as oncologists, advanced practice providers, oncology nurses and other health care professionals involved in the multidisciplinary care of patients with NSCLC.

Physicians’ Education Resource^®, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians’ Education Resource^®, LLC designates this live activity for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians’ Education Resource^®, LLC is approved by the California Board of Registered Nursing, Provider #16669, for 1.5 Contact Hours.

Medical Oncologists (ABIM)

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.