Current and Emerging Clinical Applications for Liquid Biopsies in the Management of Solid Tumors

Release Date: January 4, 2017
Expiration Date: January 4, 2018
Media: Print with online posttest, evaluation, and request for credit


This activity is designed to inform physicians about recent and anticipated advances in the use of liquid biopsies to manage patients with solid tumors.

Instructions for Participation/How to Receive Credit:

  1. Read the article in its entirety.
  2. Use the QR code or type into your Web browser to access the posttest.
  3. Complete and pass the posttest with a score of 70% or higher.
  4. Complete the evaluation and request for credit.

Target Audience

This activity is directed toward medical oncologists, primary care physicians, nurses, and nurse practitioners who treat and/or manage patients with solid tumors. Surgical oncologists, radiation oncologists, pathologists, internists, fellows, physician assistants, and other healthcare providers interested in the use of liquid biopsy in the management of solid tumors are also invited to participate.

Learning Objectives

After participating in this CME/CE activity, learners should be better prepared to:
  • Characterize the clinical potential of liquid biopsy in the era of precision medicine.
  • Describe the biologic and technologic advantages and limitations of liquid biopsy in the management of solid tumors.
  • Discuss the processes associated with the collection and analysis of circulating tumor cells (CTCs) and cell-free circulating tumor DNA (cfDNA).
  • Summarize the main findings from studies investigating the use of CTCs and cfDNA in patients with solid tumors.
  • Explain the role of next-generation sequencing in the molecular characterization of cfDNA.
  • Describe the current obstacles to the widespread implementation of liquid biopsy.

The American Journal of Hematology/ Oncology® Editorial Board

Debu Tripathy, MD
Professor and Chairman
Department of Breast Medical Oncology
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX
Disclosure: Grant/research support from Genentech/Roche, Pfizer, Puma Biotechnology Inc, and Novartis (clinical trial support contracted to the University of Southern California and MD Anderson Cancer Center); consultant for Eisai, OncoPlex Diagnostics, Merck, and Novartis.


Philip C. Mack, PhD

Adjunct Professor
UC Davis Comprehensive Cancer Center
Sacramento, CA
Professor and Vice President
California Northstate University
Elk Grove, CA
Disclosure:Grant/Research Support: Boehringer Ingelheim; consultant: AstraZeneca, Novartis, MolecularMD, Apton Biosystems, Guardant Health

Staff/Planner Disclosures and Conflict of Interest Resolution

The staff of Physicians’ Education Resource®, LLC (PER®), and the edi-torial staff of The American Journal of Hematology/Oncology® have no relevant financial relationships with commercial interests to disclose.

It is the policy of PER® to ensure fair balance, independence, objectivity, and scientific objectivity in all of our CME/CE activities. In accordance with ACCME guidelines, PER® requires everyone who is in a position to control the content of an educational activity, including spouses/partners, to disclose all relevant financial relationships with any commercial interest to participants as part of the activity planning process. PER® has implemented mechanisms to identify and resolve all conflicts of interest prior to release of this activity. 

Accreditation/Credit Designation

Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Physicians’ Education Resource®, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians’ Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669 for 1.0 Contact Hour. 

Acknowledgment of Commercial Support

This activity is funded by Physicians' Education Resource®, LLC.

Off-Label Disclosure and Disclaimer

This continuing medical and nursing education activity may or may not discuss investigational, unapproved, or off-label uses of drugs. Participants are advised to consult prescribing information for any products discussed.The information provided in this CME/CE activity is for continuing medical and nursing education purposes only andis not meant to substitute for the independent medical judgment of a physician or nurse relative to diagnostic, treatment, and management options for a specific patient’s medical condition. 


The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of Physicians’ Education Resource®, LLC. 

Contact information for questions about the activity:

Physicians’ Education Resource®, LLC 666 Plainsboro Road, Suite 356 Plainsboro, NJ 08536
Phone: (888) 949-0045

Hardware And Software Requirements

Supported Browsers
Internet Explorer v.7 or greater (for Windows) | Mozilla Firefox v.2 or greater (for Windows, Mac, Linux)

Minimum System Requirements (Windows)

  • A Pentium-based PC or compatible computer
  • At least 64MB of RAM
  • Windows 95/98/NT/ME/2000/XP/Vista system software
  • Screen resolution of 1024 x 786 or larger recommended
  • PDF Reader: Adobe Reader 5.0 or higher, Foxit Reader 2.0 or likewise

Minimum System Requirements (Mac OS)

  • A PowerPC processor-based Macintosh computer
  • At least 64MB of RAM
  • Mac OS 7.5 or later
  • Screen resolution of 1024 x 786 or larger recommended
  • PDF Reader: Adobe Reader 5.0 or higher, Foxit Reader 2.0 or likewise


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