Tenosynovial giant cell tumor (TGCT) is challenging to diagnose and manage, requiring the coordination of clinicians across specialties. In this BURST CME™ activity, 2 experts in TGCT management review the current landscape of diagnosis and treatment, including discussion of the strengths and limitations of established diagnostic approaches and an exploration of the expanding therapeutic arsenal for this disease. Multidisciplinary management of TGCT is also discussed to integrate surgical, systemic, supportive, and rehabilitative care for patients.