Accreditation/Credit Designation

Physicians’ Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians’ Education Resource®, LLC, designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians’ Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669, for 1.5 Contact Hours.

Acknowledgment of Commercial Support

This activity is supported by an educational grant from Avanir Pharmaceuticals.

Provider and Caregiver Connection: Understanding and Addressing the Effects of Pseudobulbar Affect on Patients' QoL

Release Date: March 27, 2020
Expiration Date: March 27, 2021
Media: Internet - based

Activity Overview

Pseudobulbar affect is characterized by sudden and uncontrollable outbursts of crying or laughter that are out of context with an individual’s mood or situation. The psychological consequences around family members and in social situations can be substantial, leading to isolation and depression. As a relatively rare condition, PBA is frequently misdiagnosed or underdiagnosed. Underlying neurological conditions, most commonly multiple sclerosis, amyotrophic lateral sclerosis, stroke, and traumatic brain injuries, are associated with pseudobulbar affect. Although antidepressants have been used with little evidence to treat symptoms of PBA, the approved combination therapy of dextromethorphan hydrobromide/quinidine sulfate provides significant relief to patients with PBA.

To enable earlier diagnosis and treatment of pseudobulbar affect, this 2-part Provider and Caregiver Connection™ first provides expert audio commentary and text overview of clinical aspects of pseudobulbar affect. Patient and caregiver perspectives are then provided in a panel-style discussion with faculty who cover the burden on quality of life, challenges of diagnosis, and effective treatment.

Acknowledgement of Commercial Support

This activity is supported by an educational grant from Avanir Pharmaceuticals.

Instructions for This Activity and Receiving Credit

  1. Complete the activity (including pre- and post-activity assessments).
  2. Answer the evaluation questions.
  3. Request credit using the drop-down menu.

You may immediately download your certificate.

Target Audience

This activity is intended for neurologists, psychiatrists, nurse practitioners, physician assistants, and other health care professionals involved in the management of PBA.

Learning Objectives

Upon successful completion of this educational activity, you should be better prepared to:

  • Delineate the key symptoms of PBA and its burden on patients and their caregivers
  • Diagnose PBA more promptly and accurately to enable earlier intervention
  • Evaluate the efficacy and safety of pharmacologic agents for use in patients with PBA
  • Develop evidence-based treatment strategies for individual patients with PBA to reduce symptoms and optimize outcomes

Faculty, Staff, and Planners’ Disclosures

In accordance with ACCME guidelines, PER® has identified and resolved all conflicts of interest for faculty, staff, and planners prior to the start of this activity by using a multistep process.


Gerald A. Maguire, MD
Gerald A. Maguire, MD
Professor and Chair
Psychiatry and Neuroscience
University of California, Riverside School of Medicine
Riverside, CA

Disclosures: Grant/Research Support: Axsome, Otsuka, Teva, Intracellular, Emalex; Consultant: Acadia, Emalex; Speaker’s Bureau: Otsuka, Takeda, Janssen, Sunovion, Neurocrine, Teva.

William M. Sauvé, MD
William M. Sauvé, MD
Regional Medical Director
Greenbrook TMS NeuroHealth Centers
Richmond, VA

Disclosures: no relevant financial relationships with commercial interests.

James Wymer, MD., Ph.D
James Wymer, MD., Ph.D
Director, Neuromuscular Division
University of Florida
Gainesville, FL

Disclosures: no relevant financial relationships with commercial interests.

George Handgis (Patient Interviewee)

Disclosures: no relevant financial relationships with commercial interests.

Sharon Handgis (Caregiver Interviewee)

Disclosures: no relevant financial relationships with commercial interests.

Physicians’ Education Resource®, LLC (PER®), uses a blinded peer review process. The peer reviewer discloses the following: Grant/Research Support: Biogen, Novartis; Consultant: Actelion, Biogen, Celgene, EMD Serono, Genentech, Immunic, Novartis, Sanofi, Teva, and TG Therapeutics.

The staff of Physicians' Education Resource®, LLC (PER®) have no relevant financial relationships with commercial interests to disclose.

Off-Label Disclosure and Disclaimer

This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a healthcare professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.

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