Accreditation/Credit Designation

Physicians' Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians' Education Resource®, LLC, designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Acknowledgment of Commercial Support

This activity is supported by an educational grant from Jazz Pharmaceuticals, Inc.

Hematology Briefings™: A Clinician's Guide to Identifying and Managing Hepatic VOD in Adult Patients

Release Date: September 30, 2019
Expiration Date: September 30, 2020
Media: Internet - based

Activity Overview

Severe veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is associated with a mortality rate of over 90% by ≥day 100 following hematopoietic stem cell transplantation (HSCT) and is not a disease restricted to the transplantation setting. It may also develop in patients receiving chemotherapy or calicheamicin antibody–drug conjugates not associated with HSCT. In the transplantation setting, exposure to inotuzumab or gemtuzumab prior to HSCT increases the risk of developing VOD/SOS. Early and accurate diagnosis with consistent clinical best practice in treatment and management improves outcomes for adult patients with VOD/SOS. A number of agents have recently been developed and investigated for use in both prophylaxis and treatment of this condition. Despite these developments, there is no uniform consensus on the optimal strategy for managing VOD/SOS. Variability in diagnostic protocols and subsequent management practices, as well as new developments in the treatment of this condition, have resulted in existing and emerging clinical and educational gaps.

This Hematology Briefings™ program will help clinicians meet the challenge of acquiring this knowledge by featuring a series of audio interviews with Paul G. Richardson, MD, an expert in VOD/SOS, that highlight diagnostic guidelines for VOD/SOS in adults, emerging mechanistic approaches to improve management of VOD/SOS, and the application of current and novel strategies to overcome commonly observed clinical challenges in the treatment of VOD in adult populations.

Benefits of Participating

  • Increase knowledge and competence in the effective diagnosis and risk stratification of patients with VOD/SOS
  • Learn strategies to effectively manage VOD/SOS from Dr. Paul G. Richardson, a leading expert in VOD/SOS, in patients with comorbid conditions
  • Apply insight from a real-world case example provided by Dr. Richardson to support effective clinical decision-making in your practice
  • Build confidence in your knowledge of how to optimally treat VOD/SOS with consideration for novel agents and therapeutic strategies
  • Improve knowledge of best practice recommendations for supportive care for VOD/SOS

Acknowledgement of Commercial Support

This activity is supported by an educational grant from Jazz Pharmaceuticals, Inc.

Instructions for This Activity and Receiving Credit

  • You will need to log in to participate in the activity.
  • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review videos/content until you finish the presentation.
  • At the end of the activity, “Educational Content/Audio” will be available for your reference.
  • In order to receive a CME Certificate, you must complete the activity.
  • Complete the Posttest and pass with a score of 70% or higher, complete the Evaluation, and then click on “Request for Credit.” You may immediately download a CME Certificate upon completion of these steps.

Target Audience

This educational initiative is directed toward medical oncologists and hematologists who treat patients with cancer.

Nurse practitioners, nurses, physician assistants, pharmacists, investigators, fellows, and other healthcare professionals interested in the treatment of cancer are also invited to participate.

Learning Objectives

Upon successful completion of this educational activity, you should be better prepared to:

  • Discuss recent recommendations to facilitate early diagnosis among adult patients at risk for VOD
  • Explain recent evidence that informs clinical decision-making among adult patients with VOD and ongoing trials evaluating management strategies to address unmet clinical needs in the field
  • Apply recent criteria for the diagnosis of VOD and trial findings to facilitate identification and treatment planning among adult patients with VOD

Faculty, Staff, and Planners’ Disclosures


Paul G. Richardson
Paul G. Richardson, MD
Clinical Program Leader and Director of Clinical Research Jerome Lipper Multiple Myeloma Center
Dana-Farber Cancer Institute
RJ Corman Professor of Medicine Harvard Medical School
Boston, MA

Disclosures: Grant/ Research Support: Oncopeptides, Celgene, Takeda, Bristol-Myers Squibb; Advisory Committee Member: Karyopharm, Oncopeptides, Celgene, Takeda, Amgen, Janssen, Sanofi.

PER® uses a blinded peer review process.

The staff of Physicians' Education Resource®, LLC (PER®), have no relevant financial relationships with commercial interests to disclose.

Disclosure Policy and Resolution of Conflicts of Interest (COI)

As a sponsor accredited by the ACCME, it is the policy of PER® to ensure fair balance, independence, objectivity, and scientific rigor in all of its CME activities. In compliance with ACCME guidelines, PER® requires everyone who is in a position to control the content of a CME activity to disclose all relevant financial relationships with commercial interests. The ACCME defines “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that creates a COI.

Additionally, PER® is required by ACCME to resolve all COI. PER® has identified and resolved all COI prior to the start of this activity by using a multistep process.

Off-Label Disclosure and Disclaimer

This CME activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing medical education purposes only and is not meant to substitute for the independent clinical judgment of a physician relative to diagnostic or treatment options for a specific patient’s medical condition.

The opinions expressed in the content are solely those of the individual faculty members, and do not reflect those of PER® or the company that provided commercial support for this program.

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