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Accreditation/Credit Designation

Physicians' Education Resource®, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Physicians' Education Resource®, LLC designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians' Education Resource®, LLC is approved by the California Board of Registered Nursing, Provider #16669 for 1.0 Contact Hour.

Acknowledgment of Commercial Support

This activity is supported by an educational grant from by Amgen.

Community Practice Connections™: The Role of Non-Statin Therapies for LDL-C Lowering for Management of ASCVD Risk

Release Date: September 28, 2018
Expiration Date: September 28, 2019
Media: Internet - based

Activity Overview

Statins have been the mainstream of hypercholesterolemia treatment for over 30 years, but clinicians now have effective nonstatin options when lipid-lowering goals are not met or when patients become statin intolerant. Besides bile acid binding resins and a cholesterol absorption inhibitor, 2 proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors have been available since 2015, alirocumab and evolocumab to provide a more aggressive approach to lipid-lowering.

In this Community Practice Connections™, 2 leading family-practice physicians will provide insight on statin intolerance and discuss nonstatin treatment options as well as compare and contrast indications for the PCSK9 inhibitors. Key points to incorporate PCSK9 inhibitors into clinical practice and tips to facilitate patient access will be included to readily broaden clinicians’ armamentarium of lipid-lowering treatments.

Acknowledgment of Commercial Support

This activity is supported by an educational grant from by Amgen.

Target Audience

This continuing medical education (CME) activity is primarily intended for family physicians who treat patients with cardiovascular risk factors including hypercholesterolemia.

Educational Objectives

At the conclusion of this activity, you should be better prepared to:

  • Summarize the latest guidelines and recommendations on cholesterol management from major clinical organizations
  • Review potential cholesterol-lowering therapies beyond statins, and explain when these non-statin therapies should be considered
  • State the indications in detail for proprotein convertase subtilisin kexin type 9 inhibitor (PCSK9i) therapy

Faculty, Staff, and Planners' Disclosures


Stephen A. Brunton, MD
Adjunct Clinical Professor
Department of Pharmacy Practice
Roseman University of Health Sciences
Salt Lake City, Utah

Disclosure: No relevant financial information to disclose

Michael Cobble, MD, FNLA
Canyons Medical Center
Sandy, Utah
Adjunct Faculty
University of Utah
Salt Lake City, Utah

Disclosure: Consultant: Kowa Pharmaceuticals America, Inc; Speakers Bureau: Amarin Corporation, Amgen, AstraZeneca, Kowa Pharmaceuticals America, Inc, Sanofi

The staff of Physicians' Education Resource®, LLC, (PER®) have no relevant financial relationships with commercial interests to disclose.

Disclosure Policy and Resolution of Conflicts of Interest (COI)

As a sponsor accredited by the ACCME, it is the policy of PER® to ensure fair balance, independence, objectivity, and scientific rigor in all of its CME activities. In compliance with ACCME guidelines, PER® requires everyone who is in a position to control the content of a CME activity to disclose all relevant financial relationships with commercial interests. The ACCME defines “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that creates a COI.

Additionally, PER® is required by ACCME to resolve all COI. PER® has identified and resolved all COI prior to the start of this activity by using a multistep process.

Off-Label Disclosure and Disclaimer

This CME activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing medical and nursing education purposes only, and is not meant to substitute for the independent clinical judgment of a physician relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER®.

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