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Accreditation/Credit Designation

Physicians' Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians' Education Resource®, LLC, designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians' Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669, for 1.5 Contact Hours.

Acknowledgement of Commercial Support

This activity is supported by educational grants from Regeneron Pharmaceuticals, Inc. and Sanofi Genzyme.

Community Practice Connections™: New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of Immunotherapy


Release Date: August 13, 2018
Expiration Date: August 13, 2019
Media: Internet - based
 

Activity Overview

Although most cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed early and cured with office-based therapy, advanced cases of cSCC harbor a significant morbidity and mortality risk, and have few available treatment options outside of clinical trials. In this online activity, focused on expert interviews and clinical vignettes, you will engage with renowned medical experts in the treatment of cSCC, Omid Hamid, MD, Jason J. Luke, MD, Nikhil I. Khushalani, MD, and Chrysalyne Schmults, MD, MSCE; gain insight into staging and sequencing options; and consider how emerging immunotherapy options will impact the treatment paradigm. The content and interviews are based on presentations delivered in June 2018 at the New Directions in Advanced Cutaneous Squamous Cell Carcinoma: Emerging Evidence of Immunotherapy meeting held adjunct to the 2018 American Society of Clinical Oncology Annual Meeting.
 
For busy oncologists focused on the management of complex patients with advanced or metastatic cSCC, this activity provides you with an up-to-date perspective on the efficacy and safety evidence underpinning the use of immunotherapy for this patient population.
 
Below are some clinical pearls and highlights from the activity:
  • Risk factors for the development of cSCC include cumulative sun exposure  and immunosuppression status. Immunotherapy holds promise of therapeutic benefit for most patients; however, further research is needed to determine appropriate therapies for patients who are immunosuppressed. 
  • Emerging evidence shows that immunotherapy treatment for patients with cSCC is associated with objective response rates between 40% and 50%, along with tolerable safety profiles. Expected US Food and Drug Administration approval is eagerly awaited by oncologists.
  • Treatment with immune checkpoint inhibitors provides survival benefits, but associated toxicities need to be carefully managed. Upfront educational efforts with both patients and family caregivers may encourage prompt and effective management of immune-related adverse events.
Clinical Relevance
“It is difficult to overstate the need for novel strategies in treating cutaneous squamous cell carcinoma. The current standard of care includes disfiguring surgical resections, repeated radiation, or highly toxic chemotherapy. The promise of immunotherapy both to potentially shrink tumors and to control advanced unresectable disease over indefinite periods of time is extremely exciting for patients. ”
Jason J. Luke, MD
The University of Chicago
Chicago, IL

Acknowledgement of Commercial Support

This activity is supported by educational grants from Regeneron Pharmaceuticals, Inc. and Sanofi Genzyme.

Instructions for This Activity and Receiving Credit

  • You will need to login to participate in the activity.
  • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review videos/content until you finish the presentation.
  • At the end of the activity, “educational content/video files” will be available for your reference.
  • In order to receive a CME/CE certificate, participants must complete the activity.
  • Complete the posttest and pass with a score of 70% or higher, complete the evaluation and then click on request for credit. Participants may immediately download a CME/CE certificate upon completion of these steps.


Target Audience

This educational activity is directed toward medical oncologists. Nurse practitioners, nurses, physician assistants, pharmacists, researchers, and other healthcare professionals interested in the treatment of cSCC are also invited to participate, as well as those involved in the multidisciplinary care of patients with cSCC, including dermatologists, surgeons, head and neck cancer surgeons, and Mohs surgeons.

Learning Objectives

At the conclusion of this activity, you should be better prepared to:

  • Discuss current unmet clinical needs in the management of advanced/metastatic cSCC and evidence-based recommendations for the care of patients with these tumors
  • Determine the rationale for development of cytoreductive strategies for the management of patients with advanced/metastatic cSCC
  • Report recent evidence concerning the use of emerging immunotherapeutic approaches for the treatment of patients with advanced or metastatic cSCC
  • Describe multidisciplinary approaches to plan for and proactively mitigate the impact of immune-related adverse events in patients who are undergoing treatment for advanced/metastatic cSCC
Faculty, Staff, and Planners' Disclosures

Omid Hamid, MD 
Chief, Translational Research & Immuno-Oncology
Director, Cutaneous Malignancies
The Angeles Clinic and Research Institute
Director, Experimental Therapeutics
Cedars-Sinai Medical Care Foundation
Los Angeles, CA

Disclosure: Consultant: Amgen, Novartis, Roche, BMS, Merck; Speakers’ Bureau: BMS, Genentech, Novartis, Amgen; Contracted Research for Institution: AstraZeneca, BMS, Celldex, Genentech, Immunocore, Incyte, Merck, Merck-Serono, MedImmune, Novartis, Pfizer, Rinat, Roche

Jason J. Luke, MD, FACP
Assistant Professor of Medicine
The University of Chicago Medicine
Chicago, IL
 
 

Disclosure: Grant/Research Support: AbbVie, Array, Boston Biomedical, Bristol-Myers Squibb, Celldex, CheckMate, Corvus, Delcath, Five Prime, Genentech, lmmunocore, lncyte, Medlmmune, Macrogenics, Novartis, Pharmacyclics, Palleon, Merck, Tesaro, Xencor; Consultant: 7 Hills, Actym, Amgen, Array, AstraZeneca, BeneVir, Bristol-Myers Squibb, Castle, Check-Mate, Compugen, EMO Serono, Gilead, Janssen, Merck, NewLink, Nimbus, Novartis, Palleon, RefleXion, Syndax, Tempest, WntRx; Travel: Amgen, Array, AstraZeneca, BeneVir, Bristol-Myers Squibb, Castle, CheckMate, EMD Serono, Gilead, Janssen, Merck, NewLink, Novartis, RefleXion

Nikhil I. Khushalani, MD
Vice Chair, Department of Cutaneous Oncology
Moffitt Cancer Center
Tampa, FL
 
 

Disclosure: Research Funding (Institute): BMS, Merck, Amgen, GSK, Novartis, Regeneron, HUYA; Advisory Board: Castle Biosciences, BMS, EMD Serono, Genentech, Regeneron; Data Safety Monitoring Board: AstraZeneca

Chrysalyne Schmults, MD, MSCE
Associate Professor of Dermatology
Harvard Medical School
Director, Dermatologic Surgery Center
Brigham and Women’s Hospital
Boston, MA

Disclosure: Grant/Research Support: Site PI, Regeneron EMPOWER-CSCC Trial

The staff of Physicians' Education Resource®, LLC have no relevant financial relationships with commercial interests to disclose.

Disclosure Policy and Resolution of Conflicts of Interest

As a sponsor accredited by the ACCME, it is the policy of Physicians’ Education Resource®, LLC, (PER®) to ensure fair balance, independence, objectivity, and scientific rigor in all of its CME activities. In compliance with ACCME guidelines, PER® requires everyone who is in a position to control the content of a CME activity to disclose all relevant financial relationships with commercial interests. The ACCME defines relevant financial relationships as financial relationships in any amount occurring within the past 12 months that creates a conflict of interest (COI).
 
Additionally, PER® is required by ACCME to resolve all COI. PER® has identified and resolved all COI prior to the start of this activity by using a multistep process.
 

Off-Label Disclosure and Disclaimer

This CME/CE activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME/CE activity is for continuing medical and nursing education purposes only, and is not meant to substitute for the independent clinical judgment of a physician or nurse relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER®.







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