Accreditation/Credit Designation

Physicians' Education Resource®, LLC (PER®), is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians' Education Resource®, LLC, designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physicians' Education Resource®, LLC, is approved by the California Board of Registered Nursing, Provider #16669, for 1.5 Contact Hours.

This activity is supported and entirely funded by PER.

Community Practice Connections™: 2nd Annual European Symposium on Lung Cancers™


Release Date: August 30,, 2018
Expiration Date: August 30, 2019
Media: Internet - based
 

Activity Overview

Community Practice Connections: 2nd Annual European Symposium on Lung Cancers features a summary of clinical evidence guiding best practices in the treatment of patients with non–small cell lung cancer (NSCLC), including recent developments with targeted agents and immunotherapy. Interactive clinical vignettes are followed by short video interviews with internationally renowned experts in the management of patients with NSCLC. The video interviews address decision points in the clinical vignettes and questions commonly faced in the community oncology practice setting by medical professionals engaged in the care of patients with NSCLC.


Instructions for This Activity and Receiving Credit

  • You will need to login to participate in the activity.
  • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review videos/content until you finish the presentation.
  • At the end of the activity, “educational content/video files” will be available for your reference.
  • In order to receive a CME/CE certificate, participants must complete the activity.
  • Complete the posttest and pass with a score of 70% or higher, complete the evaluation and then click on request for credit. Participants may immediately download a CME/CE certificate upon completion of these steps.


Target Audience

This educational activity is directed toward medical oncologists, radiation oncologists, thoracic surgeons, pulmonologists, and other healthcare professionals involved in the treatment and management of patients with lung cancer.

Learning Objectives

At the conclusion of this activity, you should be better prepared to:

  • Discuss state-of-the-art application of immunotherapy in metastatic non-small cell lung cancer (NSCLC)
  • Describe the emergence of immunotherapy in locally advanced NSCLC
  • Review new standards for patients with EGFR-mutated and ALK-rearranged NSCLC, and recent data on therapies to target other oncogenic drivers
  • Understand the role of liquid biopsies for treatment selection
  • Describe the pulmonologist’s perspective on best practices in lung cancer diagnosis and therapy
  • Gain insight into the therapeutic advances in small cell lung cancer (SCLC) and mesothelioma

Faculty, Staff, and Planners' Disclosure

Benjamin Besse, MD, PhD
Head of the Cancer Medicine Department
Gustave Roussy
Villejuif, France
 


Disclosure: Grant/Research Support: AstraZeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Lilly, Pfizer, Roche/Genentech, sanofi-aventis, Clovis, GlaxoSmithKline, Servier, EOS Pharmaceutical Corp., Onxeo, OncoMed, Inivata, OSE Pharma

Prof. Dr. med. Martin Reck
Head of the Thoracic Oncology and Clinical Trial Departments
LungenClinic Grosshansdorf
Grosshansdorf, Germany
 


Disclosure: Consultant/Advisory Board:Roche, Lilly, AstraZeneca, Merck Sharp & Dohme, Bristol-Myers Squibb, Boehringer Ingelheim, Pfizer, Novartis, Celgene; Speakers Bureau: Roche, Lilly, AstraZeneca, Merck Sharp & Dohme, Bristol-Myers Squibb, Boehringer Ingelheim, Pfizer, Novartis, Celgene
 

The staff of Physicians’ Education Resource®, LLC have no relevant financial relationships with commercial interests to disclose.

Disclosure Policy and Resolution of Conflicts of Interest

As a sponsor accredited by the ACCME, it is the policy of PER® to ensure fair balance, independence, objectivity, and scientific rigor in all of its CME activities. In compliance with ACCME guidelines, PER® requires everyone who is in a position to control the content of a CME activity to disclose all relevant financial relationships with commercial interests. ACCME defines relevant financial relationships as financial relationships in any amount occurring within the past 12 months that create a conflict of interest (COI).
 
Additionally, PER® is required by ACCME to resolve all COI. PER® has identified and resolved all COI prior to the start of this activity by using a multistep process.

Off-Label Disclosure and Disclaimer

This CME/CE activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing medical and nursing education purposes only, and is not meant to substitute for the independent clinical judgment of a physician or nurse relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER®.

PER Pulse™ Recaps

1 of 3

Immunotherapy in Locally Advanced NSCLC

The 2nd Annual European Symposium on Lung Cancers™, held 4-5 May, 2018, was convened to present recent advances in lung cancer, particularly in the areas of targeted therapy and immunotherapy, and discuss the integration of new approaches in the clinic. This first of 3 PER Pulse™ Recaps from the European Symposium on Lung Cancers™ focuses on the development of immunotherapy as consolidation following chemoradiation therapy (CRT) in patients with unresectable stage III non–small cell lung cancer (NSCLC).

  • In February 2018, the FDA approved durvalumab for patients with unresectable stage III NSCLC who achieve at least stable disease after concurrent CRT.
  • Approval was based on the phase III PACIFIC trial.
  • Initial results showed an 11.2-month increase in progression-free survival with durvalumab compared with placebo.
  • Subsequently, overall survival (OS) data were reported, showing a significant benefit with durvalumab (HR, 0.68; P = .0025).
  • European approval was granted in September 2018; although the US approval did not include a biomarker requirement, approval in Europe includes patients with a PD-L1 expression level of ≥1%, based on an exploratory analysis of OS by PD-L1 status.

2 of 3

Immunotherapy in Metastatic NSCLC

The 2nd Annual European Symposium on Lung Cancers™, held 4-5 May, 2018, was convened to present recent advances in lung cancer, particularly in the areas of targeted therapy and immunotherapy, and discuss the integration of new approaches in the clinic. This second of 3 PER Pulse™ Recaps from the European Symposium on Lung Cancers™ focuses on immunotherapy-based therapy in patients with newly diagnosed metastatic non–small cell lung cancer (NSCLC).

  • Single-agent immunotherapy as initial treatment was approved for patients with a PD-L1 expression level ≥50% in 2016 based on the KEYNOTE-024 trial comparing pembrolizumab to standard chemotherapy. Subsequently, the KEYNOTE-042 trial carried out this comparison with a lower PD-L1 expression cutoff of ≥1%. In the overall patient cohort, an overall survival benefit was seen with pembrolizumab, although no benefit was observed in patients with an expression level of 1% to 49%. In April 2019, the FDA expanded the approval of pembrolizumab monotherapy as initial therapy to include patients with an expression level ≥1%.
  • Immunotherapy/chemotherapy combinations have also become approved first-line options in patients with metastatic NSCLC. The combination of pembrolizumab with pemetrexed/platinum in patients with nonsquamous NSCLC received full approval from the FDA in August 2018 based on the KEYNOTE-189 trial; European approval occurred in September 2018. Also in nonsquamous NSCLC, the IMpower150 trial led to approval in the US of atezolizumab plus bevacizumab/paclitaxel/carboplatin in December 2018; European authorities approved this regimen in March 2019. For patients with squamous NSCLC, the KEYNOTE-407 trial yielded US approval of pembrolizumab plus carboplatin and either nab-paclitaxel or standard paclitaxel in October 2018. In March 2019, European approval of this regimen was granted.

3 of 3

Targeted Therapy in Advanced NSCLC: Focus on EGFR and ALK Inhibition

The 2nd Annual European Symposium on Lung Cancers™, held 4-5 May, 2018, was convened to present recent advances in lung cancer, particularly in the areas of targeted therapy and immunotherapy, and discuss the integration of new approaches in the clinic. This third of 3 PER Pulse™ Recaps from the European Symposium on Lung Cancers™ focuses on new approaches for patients with advanced non–small cell lung cancer (NSCLC) and mutations in EGFR or ALK genes.

  • For initial therapy of patients with EGFR mutation–positive NSCLC, the phase III FLAURA trial demonstrated a significant improvement in progression-free survival (PFS) with osimertinib compared with erlotinib or gefitinib; overall survival (OS) data were not mature at the time of initial reporting. These data led to approval in April 2018 by the FDA, with European approval occurring in June 2018.
  • In the phase III ARCHER 1050 trial, dacomitinib was compared with gefitinib as initial therapy in patients with EGFR mutation–NSCLC, demonstrating improved PFS and OS. Authorities in the United States granted approval in September 2018, with the European Commission granting approval in April 2019.
  • For patients with ALK-rearranged NSCLC whose disease progresses on crizotinib, several agents have been approved. However, for patients previously receiving a next-generation ALK inhibitor (ie, progressing after first-line crizotinib plus ≥1 additional ALK inhibitor or progressing on first-line alectinib or ceritinib), lorlatinib was the first agent approved, with FDA approval occurring in November 2018. In March 2019, the European Committee for Medicinal Products for Human Use recommended approval of lorlatinib.

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