Release Date: December 22, 2025
Expiration Date: December 22, 2026
Activity Overview
Lambert-Eaton myasthenic syndrome (LEMS) is a rare, frequently under-recognized paraneoplastic neurologic disorder that may occur in patients with small cell lung cancer (SCLC). Overlapping features with myasthenia gravis, chemotherapy-induced neuropathy, or deconditioning often delay diagnosis, leading to significant morbidity, functional decline, and missed opportunities to identify SCLC earlier.
This interactive, hybrid satellite symposium was presented in conjunction with the 2025 International Association for the Study of Lung Cancer (IASLC) North America Conference on Lung Cancer (NACLC) in Chicago, Illinois. Using a case-based format, our expert faculty highlight hallmark clinical clues, outline evidence-based diagnostic pathways, and provide strategies for optimizing care with available therapies and multidisciplinary coordination. By addressing real-world challenges in recognition and management, the session aims to equip clinicians with actionable tools to improve outcomes for patients with SCLC and LEMS.
This educational activity is an archive of the live virtual symposium held on December 5, 2025.
Target Audience
This educational activity is directed toward medical oncologists, pathologists, molecular pathologists, thoracic surgeons, and pharmacists involved in the management of patients with SCLC.
Learning Objectives
Upon successful completion of this activity, you should be better prepared to:
- Identify distinguishing clinical features of paraneoplastic LEMS that warrant further workup
- Apply a guideline-concordant diagnostic pathway for LEMS that incorporates findings from physical exam, electrodiagnostic studies, antibody testing, and imaging
- Initiate therapy for paraneoplastic LEMS with appropriate consideration for titration and monitoring
- Define best practices for multidisciplinary fast-track pathways with defined roles, referral SLAs, and electromyography access targets
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