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Accreditation/ Credit Designation

The University of Nebraska Medical Center, Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Nebraska Medical Center, Center for Continuing Education designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Acknowledgment of Commercial Support

This activity is supported by an educational grant from AbbVie Inc.


Medical Crossfire®: Redefining Treatment Paradigms in the Management of Chronic Lymphocytic Leukemia


Release Date: October 5, 2016
Expiration Date: October 5, 2017
Media: Internet - based

Activity Overview

This edition of Medical Crossfire®, filmed in conjunction with the 2016 Pan Pacific Lymphoma Conference, is designed to provide a dynamic discussion of changing paradigms in the care of patients with chronic lymphocytic leukemia (CLL). The rapid emergence of targeted agents has displaced traditional chemotherapeutic regimens in many settings and has helped overcome unfavorable prognostic factors, such as the chromosome 17p deletion. Nevertheless, these new agents have unique characteristics and adverse-event profiles physicians need to familiarize themselves with in order to optimize therapy for their patients with CLL.
 
Our program chair, Susan O'Brien, MD, and our expert faculty, Bruce D. Cheson, MD; John G. Gribben, MD, DSc, FRCP, FRCPath; and Jennifer A. Woyach, MD, each present a brief, 10-minute overview of key topics in the management of patients with CLL, as well as future therapeutic strategies. Each presentation is followed by an extensive panel discussion and Q&A session led by Dr. O’Brien. Throughout the activity, interactive online questions are posed to participants to assess their knowledge and facilitate self-assessment. 

 

Instructions For This Activity & Receiving Credit

  • You will need to login to participate in the activity.
  • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review videos/content until you finish the presentation.
  • At the end of the activity, "educational content/video" will be available for your reference.
  • In order to receive a CME certificate, participants must complete the activity.
  • Complete the posttest and pass with a score of 70% or higher, complete the evaluation and then click on request for credit. Participants may immediately download a CME certificate upon completion of these steps.


Target Audience

This educational activity is directed toward medical oncologists, hematologists, pathologists, clinical scientists, nurse practitioners, physician assistants, nurses, and pharmacists involved in the research and treatment of hematologic malignancies.


Educational Objectives

At the conclusion of this activity, you should be better prepared to:
 
  • Explain evolving strategies to manage CLL in the frontline setting based on methods to personalize care for patients with these hematologic malignancies
  • Assess clinical decision making concerning therapeutic sequencing and combination strategies for the treatment of CLL based on evolving data sets in multiple lines of care
  • Summarize novel pathways and compounds under investigation for their effectiveness for patients with CLL
  • Explain methods to monitor patients being treated for CLL, as well as proactively manage predictable adverse events


Faculty, and Staff Disclosures

Bruce D. Cheson, MD
Deputy Chief, Hematology-Oncology
Professor of Medicine
Head of Hematology
Georgetown University Hospital
Lombardi Comprehensive Cancer Center
Washington, DC


Disclosure: Grant/Research Support: Celgene, Gilead, Pharmacyclics, Acerta, Genentech, AbbVie Inc; Consultant: Celgene, Pharmacyclics, AbbVie Inc, Genentech.

John G. Gribben, MD, DSc, FRCP, FRCPath, FMedSci
Barts Health NHS Trust
Barts and The London School of Medicine
Queen Mary University of London
London, England, United Kingdom


Disclosure: Grant/Research Support: Janssen Pharmaceuticals Inc, Pharmacyclics; Consultant: Roche Pharmaceuticals, Genentech, Celgene, AbbVie Inc, Janssen Pharmaceuticals Inc, Pharmacyclics. 
 

Susan O’Brien, MD
Associate Director for Clinical Sciences
Chao Family Comprehensive Cancer Center
Medical Director
Sue and Ralph Stern Center for Clinical Trials & Research
Professor of Medicine
Division of Hematology/Oncology
Department of Medicine
University of California, Irvine
Orange, CA

Disclosure: Grant/Research Support: Acerta, TG Therapeutics, Regeneron, Gilead, Pharmacyclics, ProNAi; Consultant: Amgen, Celgene.
 

Jennifer A. Woyach, MD
Assistant Professor
Division of Hematology
Department of Internal Medicine
The Ohio State University
Columbus, OH

Disclosure: Grant/Research Support: Acerta Pharma, Karyopharm Therapeutics, MorphoSys AG.
 

Disclosure Policy and Resolution of Conflicts of Interest (COI)

It is the policy of the University of Nebraska Medical Center, Center for Continuing Education and PER® to ensure the fair balance, independence, objectivity, and scientific objectivity in all of our CME activities. In accordance with ACCME guidelines, the University of Nebraska Medical Center, Center for Continuing Education and PER® require everyone who is in a position to control the content of an educational activity, including spouses/partners, to disclose all relevant financial relationships with any commercial interest to participants as part of the activity planning process. The University of Nebraska Medical Center, Center for Continuing Education and PER® have implemented mechanisms to identify and resolve all conflicts of interest prior to release of this activity.

As a provider accredited by ACCME, the University of Nebraska Medical Center, Center for Continuing Education must ensure balance, objectivity, independence, and scientific rigor in its educational activities.   Presenters are encouraged to provide a balanced view of therapeutic options by utilizing either generic names or the trade names of several to ensure impartiality.

All presenters, planners, and others in a position to control continuing medical education content participating in a University of Nebraska Medical Center, Center for Continuing Education activity are required to disclose relationships with commercial interests.  A commercial interest is any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients.  Disclosure of these commitments and/or relationships is included in activity materials so that participants in the activity may formulate their own judgments in interpreting its content and evaluating its recommendations.

This activity may include presentations in which presenters may discuss off-label and/or investigational use of pharmaceuticals or instruments not yet FDA-approved.  Participants should note that the use of products outside currently FDA-approved labeling should be considered experimental and are advised to consult current prescribing information for FDA-approved indications.

The staff of the University of Nebraska Medical Center, Center for Continuing Education and Physicians’ Education Resource®, LLC (PER®) have no relevant financial relationships with commercial interests.
 

Requirements for Successful Completion

  • Once you begin the activity, please answer the demographic questions. This will allow you to proceed to the activity.
  • This activity contains one or more interactive questions. You may move forward through the activity; however, you may not go back to change answers or review content until you finish the activity.
  • At the end of the activity, an “Educational Content” link will be available for you to download content in PDF format for your reference.
  • If you close the Web browser after you complete the activity, the “Educational Content” link will disappear and you will need to review the activity in its entirety to once again access the link.
  • In order to receive a CME certificate, participants must complete the activity.
  • Click on the “Request Credits” link at the end of the activity. Complete the posttest and pass with a score of 70% or higher, complete the evaluation, and then click on request for credit. Participants may immediately download a CME certificate upon completion of these steps.


Off-Label Disclosure and Disclaimer

This CME activity may or may not discuss investigational, unapproved, or off-label uses of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options for a specific patient’s medical condition.
 
The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of the University of Nebraska Medical Center, Center for Continuing Education and Physicians’ Education Resource®, LLC, or any of the companies that provided commercial support for this activity.


Hardware And Software Requirements

Supported Browsers
Internet Explorer v.7 or greater (for Windows) | Mozilla Firefox v.2 or greater (for Windows, Mac, Linux)

Minimum System Requirements (Windows)
  • A Pentium-based PC or compatible computer
  • At least 64MB of RAM
  • Windows 95/98/NT/ME/2000/XP/Vista system software
  • Screen resolution of 1024 x 786 or larger recommended
  • PDF Reader: Adobe Reader 5.0 or higher, Foxit Reader 2.0 or likewise
Minimum System Requirements (Mac OS)
  • A PowerPC processor-based Macintosh computer
  • At least 64MB of RAM
  • Mac OS 7.5 or later
  • Screen resolution of 1024 x 786 or larger recommended
  • PDF Reader: Adobe Reader 5.0 or higher, Foxit Reader 2.0 or likewise


CME Provider Contact Information 
Brenda Ram, CMP, CHCP
University of Nebraska Medical Center, Center for Continuing Education
986800 Nebraska Medical Center
Omaha, NE  68198-6800
Tel:  402-559-4152
Fax: 402-559-5915
bram@unmc.edu
www.unmc.edu/cce





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