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Physicians' Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians' Education Resource®, LLC, designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


PER Pulse™ Recaps
for Medical Crossfire®: Integrating CDK4/6 Inhibitors Into the Management of Breast Cancers focus on key topics presented during the program. A brief overview of expert perspectives on areas of clinical challenge faced by practicing oncologists and case management decisions is provided in these summaries.

Acknowledgment of Commercial Support

This activity is supported by an educational grant from Pfizer.

Medical Crossfire®: Integrating CDK4/6 Inhibitors into the Management of Breast Cancers

Release Date: May 26, 2016
Expiration Date: May 26, 2017
Media: Internet - based

Activity Overview

This edition of Medical Crossfire®, filmed in conjunction with the 33rd Annual Miami Breast Cancer Conference®, is designed to provide a dynamic discussion of current and evolving paradigms in the use of CDK inhibition to treat breast cancer, accompanied by discussion of strategies for applying emerging data to clinical practice to improve outcomes for patients.
Our Program Chairs, Debu Tripathy, MD, and Joyce O'Shaughnessy, MD, and our expert faculty, Kimberly Blackwell, MD, and Andrew Seidman, MD, engage in case-based discussions of clinical strategies regarding the use of CDK inhibition, and offer expert perspectives on the latest clinical evidence and practice recommendations, including dose adjustments for adverse-event management.
The activity begins with a 15-minute didactic overview by Dr. Tripathy on treatment algorithms, mechanisms of action of common therapies, relevant key trial data, clinical dilemmas, as well as new drugs and emerging indications. This is followed by a panel discussion about first-line treatment selection, molecular testing, monitoring for treatment response and progression of disease, and adverse-event management. Next, Dr. Blackwell leads a case presentation and panel discussion of a woman with ER-positive, HER2-negative, newly diagnosed, metastatic breast cancer. which is followed by case presentations and extended panel discussion. Finally, Dr. Seidman presents a case and leads the panel in a discussion of a postmenopausal woman with ER-positive, HER2-negative, metastatic breast cancer that has progressed on endocrine therapy. Throughout the activity, interactive online questions are posed to participants to assess knowledge and facilitate self-assessment. The extended discussion format of this activity allows ample time for examining the nuances and challenges faced by clinicians in everyday practice. 

CME Activity Table of Contents

  • How Do We Treat With Hormonal Therapy in the Metastatic Setting?
    Debu Tripathy, MD
  • Medical Crossfire
    Kim Blackwell, MD; Joyce O'Shaughnessy, MD; Andrew Seidman, MD; Debu Tripathy, MD
    • First-line treatment selection
    • Molecular testing
    • Monitoring treatment response and disease progression
    • Cyclin-dependent kinase inhibitor‒associated neutropenia
    • Case 1 description and discussion: First-line therapy for ER-positive, HER2-negative, metastatic breast cancer
    • Case 2 description and discussion: Treatment of ER-positive, HER2-negative, metastatic breast cancer after progression on endocrine therapy

Instructions For This Activity & Receiving Credit

  • You will need to login to participate in the activity.
  • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review videos/content until you finish the presentation.
  • At the end of the activity, "educational content/video" will be available for your reference.
  • In order to receive a CME certificate, participants must complete the activity.
  • Complete the posttest and pass with a score of 70% or higher, complete the evaluation and then click on request for credit. Participants may immediately download a CME certificate upon completion of these steps.

Target Audience

This educational activity is directed toward medical, surgical, and radiation oncologists interested in the treatment of patients with breast cancer. Fellows, nurse practitioners, nurses, physician assistants, pharmacists, researchers, and other healthcare professionals interested in the treatment of breast cancer may also participate.

Educational Objectives

At the conclusion of this activity, you should be better prepared to:
  • Explain the mechanism of action of CDK4/6 inhibition in the treatment of metastatic breast cancer
  • Discuss the role of emerging CDK4/6 inhibitory therapies in the treatment of metastatic breast cancer
  • Evaluate new and emerging clinical trial data that may change standards of care for patients with metastatic breast cancer
  • Identify strategies for the mitigation and management of predictable adverse events associated with emerging CDK4/6 inhibitory therapies in the management of metastatic breast cancer

Faculty, Staff, and Planners' Disclosures

Program Co-Chairs

Debu Tripathy, MD
Professor and Chair
Department of Breast Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, TX


Joyce A. O'Shaughnessy, MD
Chair, Breast Cancer Research
Celebrating Women Chair in Breast Cancer Research
Baylor Charles A. Sammons Cancer Center
Texas Oncology
The US Oncology Network
Dallas, TX


Kimberly L. Blackwell, MD
Professor of Medicine
Assistant Professor of Radiation Oncology
Duke University Medical Center
Durham, NC


Andrew D. Seidman, MD
Attending Physician, Breast Cancer Medicine Service
Memorial Sloan Kettering Cancer Center
New York, NY

The following individuals have no relevant financial relationships with commercial interests to disclose:

The staff of Physicians' Education Resource®, LLC

The following individuals have no relevant financial relationships with commercial interests to disclose:

Kimberly L. Blackwell, MD Grant/Research Support: Celgene, Genentech, Pfizer, Novartis; Consultant: Amgen, Celgene, Eli Lilly, Genentech, Incyte Corporation, Novartis, Pfizer, Roche, Sandoz, Spectrum; Joyce A. O'Shaughnessy, MD – Consultant: Arno Therapeutics, AstraZeneca, Celgene, Corcept, Eisai, Genentech, GSK, Lilly, J&J, Merrimack, Novartis, Pfizer, Roche, Sanofi, Takeda, Medfusion; Andrew D. Seidman, MD ‒ Grant/Research Support: Novartis, Bayer; Consultant: Novartis, Genentech, Merrimack, Kadmon, Pfizer; Speakers Bureau: Celgene, Genomic Health, Novartis, Genentech, Eisai; Debu Tripathy, MD – Grant/Research Support: Novartis; Consultant: Nektar, Novartis, Puma Biotechnology.

Disclosure Policy and Resolution of Conflicts of Interest (COI)

It is the policy of Physicians' Education Resource®, LLC, (PER®) to ensure fair balance, independence, objectivity, and scientific rigor in all of our CME activities. In accordance with ACCME guidelines, PER® requires everyone who is in a position to control the content of an educational activity, including spouses/partners, to disclose all relevant financial relationships with any commercial interest to participants as a part of the activity planning process. PER® has implemented mechanisms to identify and resolve all conflicts of interest prior to release of this activity.

Off-Label Disclosure and Disclaimer

This CME activity may or may not discuss investigational, unapproved, or off-label uses of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing medical education purposes only, and is not meant to substitute for the independent medical judgment of a physician or nurse relative to diagnostic, treatment, or management options for a specific patient's medical condition.

The opinions expressed in the content are solely those of the individual faculty members, and do not reflect those of Physicians' Education Resource®, LLC, or any of the companies that provided commercial support for this activity.

Hardware And Software Requirements

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Internet Explorer v.7 or greater (for Windows) | Mozilla Firefox v.2 or greater (for Windows, Mac, Linux)

Minimum System Requirements (Windows)
  • A Pentium-based PC or compatible computer
  • At least 64MB of RAM
  • Windows 95/98/NT/ME/2000/XP/Vista system software
  • Screen resolution of 1024 x 786 or larger recommended
  • PDF Reader: Adobe Reader 5.0 or higher, Foxit Reader 2.0 or likewise
Minimum System Requirements (Mac OS)
  • A PowerPC processor-based Macintosh computer
  • At least 64MB of RAM
  • Mac OS 7.5 or later
  • Screen resolution of 1024 x 786 or larger recommended
  • PDF Reader: Adobe Reader 5.0 or higher, Foxit Reader 2.0 or likewise

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