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Accreditation/Credit Designation

Physicians' Education Resource®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Physicians' Education Resource®, LLC, designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Acknowledgement of Commercial Support

This activity is supported by an educational grant from Clovis Oncology, Inc.

Medical Crossfire®: Defining New Roles for the Application of PARP Inhibition Strategies in Multiple Tumor Types

Release Date: December 31, 2017
Expiration Date: December 31, 2018
Media: Internet - based


Activity Overview

This online activity features an expert panel discussion of current and emerging roles for PARP inhibitors in the management of patients with ovarian, breast, and prostate cancer. Our panel of experts will use the growing foundation of clinical evidence pertaining to PARP inhibitor use to address several clinical issues, including strategies to optimize patient selection, clinical testing approaches, and potential application of PARP inhibitors in different lines of therapy. This activity will also investigate the mechanistic underpinnings of PARP inhibitor therapy, as well as which lessons from key PARP inhibitor studies may potentially be applied across different cancer types. Our panelists will conclude with a discussion of clinical cases and potential applications of PARP inhibitor therapy in different tumor types.

Acknowledgement of Commercial Support

This activity is supported by an educational grant from Clovis Oncology, Inc.

CME Table of Contents

  • Introduction
  • Overview of PARP Inhibition and Synthetic Lethality
  • Medical Crossfire 1: Focus on Ovarian Cancer
  • Medical Crossfire 3: Focus on Prostate Cancer
  • Clinical Cases and Potential PARP Inhibitor Applications
  • Conclusion

Requirements for Successful Completion

  • You will need to login to participate in the activity.
  • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review videos/content until you finish the presentation.
  • At the end of the activity, “educational content/video” will be available for your reference.
  • In order to receive a CME certificate, participants must complete the activity.
  • Complete the posttest and pass with a score of 70% or higher, complete the evaluation and then click on request for credit. Participants may immediately download a CME certificate upon completion of these steps.

Target Audience

This educational activity is directed toward medical oncologists, hematologists, pathologists, and fellows who treat patients with cancer. Nurse practitioners, nurses, physician assistants, pharmacists, researchers, and other healthcare professionals interested in the treatment of cancer may also participate.

Learning Objectives

At the conclusion of this activity, you should be better prepared to:

  • Determine key molecular underpinnings that provide the rationale for the targeting and investigation of PARP inhibition strategies for cancer treatment
  • Report pivotal and emerging evidence concerning the efficacy and safety of PARP inhibition strategies for the treatment of ovarian, breast, and prostate cancers
  • Place key trial evidence in the context of unmet clinical needs in the field and evolving treatment paradigms among solid tumors for which PARP inhibitor approaches have been investigated

Faculty, Staff, and Planners' Disclosures


Mark E. Robson, MD
Attending Physician
Clinical Genetics and Breast Medicine Services
Clinic Director, Clinical Genetics Service
Memorial Sloan Kettering Cancer Center
New York, NY

Disclosure: Grant/Research Support: AztraZeneca, AbbVie, BioMarin; Consultant: McKesson, AstraZeneca NY


Maurie Markman, MD
President, Medicine & Science
Cancer Treatment Centers of America
Clinical Professor of Medicine
Drexel University College of Medicine
Philadelphia, PA

Disclosure: Consultant: Celgene; Speaker’s Bureau: Clovis, AstraZeneca, Millennium, Merck, Celgene

Alicia K. Morgans, MD, MPH
Associate Professor of Medicine
Northwestern University Feinberg School of Medicine
Chicago, IL

Disclosure: Grant/Research Support: Prostate Cancer Foundation; Consultant: AstraZeneca, Janssen, Genentech

The staff of Physicians' Education Resource®, LLC have no relevant financial relationships with commercial interests to disclose.

Disclosure Policy and Resolution of Conflicts of Interest (COI)

As a sponsor accredited by the ACCME, it is the policy of PER® to ensure fair balance, independence, objectivity, and scientific rigor in all of its CME activities. In compliance with ACCME guidelines, PER® requires everyone who is in a position to control the content of a CME activity to disclose all relevant financial relationships with commercial interests. The ACCME defines “relevant financial relationships” as financial relationships in any amount occurring within the past 12 months that creates a COI.

Additionally, PER® is required by ACCME to resolve all COI. PER® has identified and resolved all COI prior to the start of this activity by using a multistep process.

Off-Label Disclosure and Disclaimer

This CME activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing education purposes only, and is not meant to substitute for the independent medical judgment of a physician or nurse relative to diagnostic, treatment, or management options for a specific patient's medical condition.

The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any of the companies that provided commercial support for this activity.

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